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Hormone replacement therapy : HRT and menopause

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Try out PMC Labs and tell us what you think. Learn More. Menopause is one of the most significant events in a woman's life and brings in a number of physiological changes that affect the life of a woman permanently. There have been a lot of speculations about the symptoms that appear before, during and after the onset of menopause. These symptoms constitute the postmenopausal syndrome; they are impairing to a great extent to the woman and management of these symptoms has become an important field of research lately. This chapter attempts to understand these symptoms, the underlying pathophysiology and the management options available. Menopause is the permanent cessation of menstruation resulting in the loss of ovarian follicle development.

Aim out PMC Labs and tell us what you think. Learn More. It is important to review the goals of hormone-replacement therapy HRT —for case, treatment of menopausal symptoms vs anticipation of osteoporosis—with the patient before initiating therapy table 1. Efficacy of HRT should be assessed after 4 en route for 6 weeks; doses can be titrated upward until symptoms are relieved. The need for continued therapy can be evaluated every 4 to 6 months. HRT may be given orally, transdermally, or intravaginally in either continuous before cyclical schedules.

The results of large clinical trials allow led physicians and patients to ask the safety of hormone therapy designed for menopause. In the past, physicians prescribed hormone therapy to improve overall fitness and prevent cardiac disease, as able-bodied as for symptoms of menopause. As a result, in women with a uterus, it is recommended that physicians prescribe amalgamation therapy only to treat menopausal symptoms such as vasomotor symptoms hot flashes and vaginal atrophy, using the smallest effective dosage for the shortest achievable duration. Although estrogen is the a good number effective treatment for hot flashes, nonhormonal alternatives such as low-dose paroxetine, venlafaxine, and gabapentin are effective alternatives.

It occurs because a woman stops ovulating releasing a mature egg once glossy magazine , and her ovaries no longer produce oestrogen one of the lady sex hormones. It is a accepted event that marks the end of the reproductive years, just as the first menstrual period during puberty marks the start. Many women, although not all, experience uncomfortable symptoms before after that after menopause, including hot flushes, dark sweats, sleep disturbance and vaginal aridity. These symptoms and physical changes be able to be managed in various ways, as well as lifestyle changes such as healthier consumption and increased exercise, and by hormone replacement therapy HRT. HRT is old to treat menopausal symptoms. While HRT reduces the likelihood of some devastating diseases such as osteoporosis, colorectal bowel cancer and heart disease, it can increase the chances of developing a blood clot when given in bar form or breast cancer when a few types are used long-term. For women who experience premature or early menopause, HRT is strongly recommended until the average age of menopause around 51 years , unless there is a particular reason for a woman not to take it. Other therapies, as well as vaginal oestrogen products, antidepressants or erstwhile medications, may be used depending arrange the symptoms and risk factors. Ask for advice from your doctor.

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